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Polymorphism in the pharmaceutical industry by Rolf Hilfiker

Polymorphism in the pharmaceutical industry Rolf Hilfiker ebook
Format: pdf
ISBN: 3527311467, 9783527311460
Publisher: Wiley-VCH
Page: 433

What if scientists could make better use of technology to predict which drugs will work and pinpoint Now you need to know something about genetic polymorphisms (gene variants) that each individual may carry. The pharmaceutical industry (active ingredients and excipients). Pharmaceutical companies could exclude those people who are known to have a negative response to the drug, from the clinical trials. Integrated Process Research and Development by Solvias: Basis of an Efficient and Successful Drug Substance Development in the Pharma Industry. The knowledge of the effects of polymorphism of genes for the enzymes involved in drug metabolism, like those belonging to the family of cytochrome P450 can be applied in drug delivery, development and the clinical use of drugs. Identification and Quantification of Polymorphism in the Pharmaceutical Compound Diclofenac Acid by Terahertz Spectroscopy and Solid-State Density Functional Theory. Category: Drug Solid state investigations including salt selection, polymorphism screening, and crystallization optimization programs enable customers to prepare the optimal solid form of a drug substance with well-defined properties for manufacture of the corresponding drug product. Polymorphism and Crystallisation in Modern Pharmaceuticals by Pharma IQ - Polymorphism and crystallisation are among the most important and challenging areas of pharmaceuticals today, with new polymorph discoveries harbouring the potential to dramatically change the prop. 2009;11(4):740-6; Govindarajan R, Suryanarayanan R. Every year, the pharmaceutical industry invests billions of dollars in testing drugs that are eventually abandoned because they don't work or cause side effects. "The polymorph issue is so important to the pharmaceutical industry," Jerry Atwood of the University of Missouri-Columbia, told Science Service. The benefits of pharmacogenomics are numerous. To overcome these challenges, the pharmaceutical industry is urgently searching for 2 solutions: “validated” gene targets and biomarkers that predict cardiovascular outcomes in a clinical trial (1,2). "Genetic testing is rapidly becoming affordable, and some companies have started offering tests with single nucleotide polymorphism microarrays for less than $300 per person," the researchers say. That is, it is not a man-made invention but a property of each substance. Avoiding action has not yet widely been taken on polymorphism by the global pharmaceutical industry, so it is worth repeating the story. Department of Chemistry Polymorph detection and quantification in crystalline materials is a principle interest of the pharmaceutical industry. Polymorphism – is your pharmaceutical company in good shape? Processing-induced Phase Transformations and Their Implications on Pharmaceutical Product Quality. Q: Is genomic sequencing also part of the picture?